Inactivation of Chemotherapeutic Agents by Clostridia
نویسندگان
چکیده
منابع مشابه
Oncolysis by Clostridia. Iii. Effects of Clostridia and Chemotherapeutic Agents on Rodent Tumors.
Intravenously injected spores of a number of species of nonpathogenic clostridia localized and germinated in tumor tissue but not in normal tissues of the mouse. In tumors of sufficient size liquefaction of an apparently substantial amount of viable tumor tissue occurred leading to statistically significant reduction of tumor weight in treated animals. Conditions for the quantitative measuremen...
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Steroid hormones reduced in ring-A are devoid of hormonal activity. In metabolic experiments we found that human fecal flora reduced the delta 4-3-keto structure of natural progestins to 3 alpha-hydroxy, 5 beta-steroid metabolites (3 alpha,5 beta) and of synthetic progestins to a mixture of 3 alpha,5 beta and 3 beta,5 beta compounds. 3 alpha,5 beta-Reductase was synthesized by Clostridium parap...
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While colony formation assays provide sensitive indices of tumor cell proliferation and growth inhibition imposed by many chemotherapeutic agents, drugs which require metabolic activation lack activity in such assays. In the present study, we have utilized freshly isolated rat hepatocytes for the activation of drugs which are metabolized by hepatic microsomal as well as extra-microsomal enzymes...
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ژورنال
عنوان ژورنال: Nippon Saikingaku Zasshi
سال: 1969
ISSN: 1882-4110,0021-4930
DOI: 10.3412/jsb.24.281